Breast cancer is a leading cause of death among women worldwide, emphasizing the need for early detection and accurate diagnosis. As such Ultrasound Imaging, a reliable and cost-effective tool, is used for this purpose, however the sensitive nature of medical data makes it challenging to develop accurate and private artificial intelligence models. A solution is Federated Learning as it is a promising technique for distributed machine learning on sensitive medical data while preserving patient privacy. However, training on non-Independent and non-Identically Distributed (non-IID) local datasets

Capturing the diverse microbiota from healthy and/or stress resilient plants for further preservation and transfer to unproductive and pathogen overloaded soils, might be a tool to restore disturbed plant-microbe interactions. Here, we introduce Aswan Pink Clay as a low-cost technology for capturing and storing the living root microbiota. Clay chips were incorporated into the growth milieu of barley plants and developed under gnotobiotic conditions, to capture and host the rhizospheric microbiota. Afterward, it was tested by both a culture-independent (16S rRNA gene metabarcoding) and

This paper tackles the problem of generating pho-torealstic images of synthetically rendered human avatar faces from computer graphics engines, our approach leverages the high capabilities of generative models as StyleGAN that can generate high quality human faces that are hard to distinguish from real human faces images. We present a framework that effectively bridges the gap between synthetic and real domain through Single shot GAN inversion that maps the synthetic image into the real latent space of StyleGAN. Benchmarks and Quantitative results show that our method demonstrate significant

Precision medicine has gained considerable popularity since the “one-size-fits-all” approach did not seem very effective or reflective of the complexity of the human body. Subsequently, since single-omics does not reflect the complexity of the human body's inner workings, it did not result in the expected advancement in the medical field. Therefore, the multi-omics approach has emerged. The multi-omics approach involves integrating data from different omics technologies, such as DNA sequencing, RNA sequencing, mass spectrometry, and others, using computational methods and then analyzing the

In a search for new drug candidates for one of the neglected tropical diseases, leishmaniasis, twenty quinoline-isatin hybrids were synthesized and tested for their in vitro antileishmanial activity against Leishmania major strain. All the synthesized compounds showed promising in vitro activity against the promastigote form in a low micromolar range (IC50 = 0.5084–5.9486 μM) superior to the reference miltefosine (IC50 = 7.8976 μM). All the target compounds were then tested against the intracellular amastigote form and showed promising inhibition effects (IC50 = 0.60442–8.2948 μM versus 8.08

Hypoxia is one of the main hallmarks of hepatocellular carcinoma (HCC) resulting from improper oxygenation and insufficient nourishment of the HCC microenvironment. The effect of hypoxia is mediated by hypoxia-inducible factor-1A (HIF-1A) via targeting various downstream pathways, including glycolysis, angiogenesis, and survival signaling. However, HCC cell lines in a 2-dimensional (2D) setting do not resemble the metabolic signature of HCC. Here we aim to overcome these limitations by developing an HCC organoid that recapitulates the HIF-1A metabolic shift. The enrichment analysis of the RNA

Severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) is a worldwide health concern, and new treatment strategies are needed. Targeting inflammatory innate immunity pathways holds therapeutic promise, but effective molecular targets remain elusive. Here, we show that human caspase-4 (CASP4) and its mouse homolog, caspase-11 (CASP11), are up-regulated in SARS–CoV-2 infections and that CASP4 expression correlates with severity of SARS–CoV-2 infection in humans. SARS–CoV-2–infected Casp112/2 mice were protected from severe weight loss and lung pathology, including blood vessel damage

Uni-Buddy is an advanced AI system developed to simplify university life at Nile University. It efficiently handles questions in everyday language, accesses real-time university databases, and simultaneously provides accurate responses for multiple users. Its goals include assisting with course registration, academic advising, financial inquiries, campus navigation, and research support. The evaluation demonstrates Uni-Buddy's user-friendly design, effective navigation, language comprehension, and database connectivity proficiency. Compared to similar studies, it stands out for its ease of use

Recently, sequencing technologies have become readily available, and scientists are more motivated to conduct metagenomic research to unveil the potential of a myriad of ecosystems and biomes. Metagenomics studies the composition and functions of microbial communities and paves the way to multiple applications in medicine, industry, and ecology. Nonetheless, the immense amount of sequencing data of metagenomics research and the few user-friendly analysis tools and pipelines carry a new challenge to the data analysis. Web-based bioinformatics tools are now being developed to facilitate the

Genomic microarray databases encompass complex high dimensional gene expression samples. Imbalanced microarray datasets refer to uneven distribution of genomic samples among different contributed classes which can negatively affect the classification performance. Therefore, gene selection from imbalanced microarray dataset can give rise to misleading, and inconsistent nominated genes that would alter the classification performance. Such unsatisfactory classification performance is due to the skewed distribution of the samples across the microarrays toward the majority class. In this paper, we