Background: Hepatocellular carcinoma (HCC) is a common and aggressive malignancy. Despite of the improvements in its treatment, HCC prognosis remains poor due to its recurrence after resection. This study provides complete genetic profile for Egyptian HCC. Genome-wide analyses were performed to identify the predictive signatures. Patients and Methods: Liver tissue was collected from 31 patients

Background: Over the past decade the workflow system paradigm has evolved as an efficient and user-friendly approach for developing complex bioinformatics applications. Two popular workflow systems that have gained acceptance by the bioinformatics community are Taverna and Galaxy. Each system has a large user-base and supports an ever-growing repository of application workflows. However, workflows

In many data mining and machine learning applications, data may be easy to collect. However, labeling the data is often expensive, time consuming or difficult. Such applications give rise to semi-supervised learning techniques that combine the use of labelled and unlabelled data. Co-training is a popular semi-supervised learning algorithm that depends on splitting the features of a data set into

Human action recognition is an important area of research in computer vision. Its applications include surveillance systems, patient monitoring, human-computer interaction, just to name a few. Numerous techniques have been developed to solve this problem in 2D and 3D spaces. However most of the existing techniques are view-dependent. In this paper we propose a novel view-independent action

Software issues related to automotive controls account for an increasingly large percentage of the overall vehicles recalled. To alleviate this problem, vehicle diagnosis and maintenance systems are increasingly being performed remotely, that is while the vehicle is being driven without need for factory recall and there is strong consumer interest in Remote Diagnosis and Maintenance (RD&M) systems

Background: Given a set of DNA sequences s1,..., st, the (l, d) motif problem is to find an l-length motif sequence M, not necessary existing in any of the input sequences, such that for each sequence si, 1 ≤ i ≤ t, there is at least one subsequence differing with at most d mismatches from M. Many exact algorithms have been developed to solve the motif finding problem in the last three decades

In this work, a novel active shape model (ASM) paradigm is proposed to segment the right ventricle (RV) in cardiac magnetic resonance image sequences. The proposed paradigm includes modifications to two fundamental steps in the ASM algorithm. The first modification includes employing the 2D-Principal Component Analysis (PCA) to capture the inter-profile relations among shape’s neighboring

Given two long strings S and T, representing two genomic sequences, and given a user defined threshold ℓ, the problem of computing maximal exact matches (MEMs) is to find each triple (p 1,p 2,l) specifying two matching substrings S[p 1..p 1 + l - 1] = T[p 2..p 2 + l - 1], such that l ≥ ℓ and S[p 1 - 1] ≠ T[p 2 - 1] and S[p 1 + l] ≠ T[p 2 + l]. Computing MEMs is a major problem in bioinformitcs

Age-related macular degeneration (AMD) is a major cause of blindness and visual impairment in older adults. The wet form of the disease is characterized by abnormal blood vessels forming a choroidal neovascular membrane (CNV), that result in destruction of normal architecture of the retina. Current evaluation and follow up of wet AMD include subjective evaluation of Fluorescein Angiograms (FA) to

Diagnosis of Diabetic Macular Edema (DME) from Fundus Fluorescein Angiography (FFA) image sequences is a standard clinical practice. Nevertheless, current methods depend on subjective evaluation of the amount of fluorescein leakage in the images which lack reproducibility and require well-trained grader. In this work, we present a method for processing FFA images to generate a fluorescein leakage