Medicines based on messenger RNA (mRNA) hold immense potential, as evidenced by their rapid deployment as COVID-19 vaccines. However, worldwide distribution of mRNA molecules has been limited by their thermostability, which is fundamentally limited by the intrinsic instability of RNA molecules to a chemical degradation reaction called in-line hydrolysis. Predicting the degradation of an RNA molecule is a key task in designing more stable RNA-based therapeutics. Here, we describe a crowdsourced machine learning competition (‘Stanford OpenVaccine’) on Kaggle, involving single-nucleotide

Since its emergence as a pandemic in March 2020, coronavirus disease (COVID-19) outcome has been explored via several predictive models, using specific clinical or biochemical parameters. In the current study, we developed an integrative non-linear predictive model of COVID-19 outcome, using clinical, biochemical, immunological, and radiological data of patients with different disease severities. Initially, the immunological signature of the disease was investigated through transcriptomics analysis of nasopharyngeal swab samples of patients with different COVID-19 severity versus control

Combinations of direct-acting antivirals are needed to minimize drug resistance mutations and stably suppress replication of RNA viruses. Currently, there are limited therapeutic options against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and testing of a number of drug regimens has led to conflicting results. Here, we show that cobicistat, which is an FDA-approved drug booster that blocks the activity of the drug-metabolizing proteins cytochrome P450-3As (CYP3As) and P-glycoprotein (P-gp), inhibits SARS-CoV-2 replication. Two independent cell-to-cell membrane fusion

This paper describes our submission UFAL MULTIVEC to the WMT16 Quality Estimation Shared Task, for English- German sentence-level post-editing effort prediction and ranking. Our approach exploits the power of bilingual distributed representations, word alignments and also manual post-edits to boost the performance of the baseline QuEst++ set of features. Our model outperforms the baseline, as well as the winning system in WMT15, Referential Translation Machines (RTM), in both scoring and ranking sub-tasks. © 2016 Association for Computational Linguistics.

Human action recognition is an important area of research in computer vision. Its applications include surveillance systems, patient monitoring, human-computer interaction, just to name a few. Numerous techniques have been developed to solve this problem in 2D and 3D spaces. However 3D imaging gained a lot of interest nowadays. In this paper we propose a novel view-independent action recognition algorithm based on fusion between a global feature and a graph based feature. We used the motion history of skeleton volumes; we compute a skeleton for each volume and a motion history for each action

The internet of things (IoT) has provided a promising opportunity to build powerful systems and applications. Security is the main concern in IoT applications due to the privacy of exchanged data using limited resources of IoT devices (sensors/actuators). In this paper, we present a classification of IoT modes of operation based on the distribution of IoT devices, connectivity to the internet, and the typical field of application. It has been found that the majority of IoT services can be classified into one of four IoT modes: Gateway, device to device, collaborative, and centralized. The

Cloud computing provides a promising solution to the big data problem associated with next generation sequencing applications. The increasing number of cloud service providers, who compete in terms of performance and price, is a clear indication of a growing market with high demand. However, current cloud computing based applications in bioinformatics do not profit from this progress, because they are still limited to just one cloud service provider. In this paper, we present different use case scenarios using hybrid services and resources from multiple cloud providers for bioinformatics

Image denoising is of paramount importance in image processing. In this paper, we propose a new design technique for the design of Double density Discrete Wavelet Transform (DD DWT) AND DD CWT filter bank structure. These filter banks satisfy the perfect reconstruction as well as alias free properties of the DWT. Next, we utilized this filter bank structure in image denoising. Our denoising scheme is based on utilizing the interscale correlation/interscale dependence between wavelet coefficients of a DD DWT of the noisy image. This is known as the Bivariate Shrinkage scheme. More precisely, we

The contribution of this paper is twofold. First, we provide new theoretical insights into the relationship between a string and its reverse: If the Burrows-Wheeler transform (BWT) of a string has been computed by sorting its suffixes, then the BWT and the longest common prefix array of the reverse string can be derived from it without suffix sorting. Furthermore, we show that the longest common prefix arrays of a string and its reverse are permutations of each other. Second, we provide a parallel algorithm that, given the BWT of a string, computes the BWT of its reverse much faster than all

We propose an Automatic Gene Ontology (AGO) software as a flexible, open-source Matlab software tool that allows the user to easily compare the results of the bicluster and cluster methods. This software provides several methods to differentiate and compare the results of candidate algorithms. The results reveal that bicluster/cluster algorithms could be considered as integrated modules to recover the interesting patterns in the microarray datasets. The further application of AGO could to solve the dimensionality reduction of the gene regulatory networks. Availability: AGO and help file is